![]() Thus, active controls act to damper fluctuations due to random noise that shift actual operating conditions from the preset states. The traditional model of control assumes that healthy human physiological systems preserve steadiness by self-regulating their activity reducing fluctuations around a homeostatic equilibrium point. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.įunding: The research leading to these results has received funding from: 1. Received: FebruAccepted: Published: June 26, 2014Ĭopyright: © 2014 Zappasodi et al. PLoS ONE 9(6):Įditor: Helmut Ahammer, Medical University of Graz, Austria ![]() FDasy result highlights the functional relevance of the balance between homologous brain structures’ activities in stroke recovery.Ĭitation: Zappasodi F, Olejarczyk E, Marzetti L, Assenza G, Pizzella V, Tecchio F (2014) Fractal Dimension of EEG Activity Senses Neuronal Impairment in Acute Stroke. This picture is coherent with neuronal activity complexity decrease paired to a reduced repertoire of functional abilities. This decrease seems to reveal the intimate nature of structure-function unity, where the regional neural multi-scale self-similar activity is impaired by the anatomical lesion. FD in our patients captured the loss of complexity reflecting the global system dysfunction resulting from the structural damage. Larger FDasy in acute phase was paired to a worse clinical recovery at six months. FD decrease was associated to alpha increase and beta decrease of oscillatory activity power. FD was smaller in patients than in controls (1.447☐.092 vs 1.525☐.105) and its reduction was paired to a worse acute clinical status. Highuchi FD, its inter-hemispheric asymmetry (FDasy) and spectral band powers were calculated for EEG signals. National Health Institute Stroke Scale (NIHss) was collected at T0 and 6 months later. Resting EEG was collected in 36 patients 4–10 days after a unilateral ischemic stroke in the middle cerebral artery territory and 19 healthy controls. Under the hypothesis that the fractal dimension (FD) of the electroencephalographic signal (EEG) is optimally sensitive to the neuronal dysfunction secondary to a brain lesion, we tested the FD’s ability in assessing two key processes in acute stroke: the clinical impairment and the recovery prognosis. Thus, the complexity of its dynamics, associated to efficient processing and functional advantages, is expected to be captured by a measure of its scale-free (fractal) properties.
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